Li, Young, Colburn and Hua, and Mr. Saud determined the effects cryptotanshinone CPT , an extract from herbal medicine, on colorectal cancer cell proliferation and growth.
Their study showed that CPT inhibited the growth and cell viability of multiple colorectal cancer cell lines. CPT inhibited activation of Signal transducer and activator of transcription 3 Stat3 , a transcription factor that mediates expression of many genes known to regulated tumor growth.
Their findings suggest that CPT could be used for both prevention and treatment of colorectal cancer by inhibiting activation of Stat3. Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro. Mol Cell Biochem. More compound screenings on NCI60 human cancer cell lines are under testing.
While NCI supported research in individual topics related to TCM, such as acupuncture, these were the first NCI grants to support the development of an international collaborative partnership to study multiple aspects of TCM.
Supportive Cancer Care with Chinese Medicine
Researchers with the center investigated the benefits of some traditional Chinese medicine TCM treatments for cancer patients. This work was advanced further under a new 4-year cooperative agreement, which was also extended for two additional years. The investigators completed Phase I clinical trials on huachansu a TCM therapy derived from sterilized toad skin extract , acupuncture to prevent prolonged postoperative ileus, and qigong for women with breast cancer. Phase II clinical trials of huachansu combined with gemcitabine in patients with advanced pancreatic cancer, and acupoint stimulation to prevent chemotherapy-induced nausea and vomiting were finalized and data analyses are ongoing.
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Another study combining tai chi and qigong was completed and the results have showed that these mind-body techniques could lower distress and lead to improvements of different aspects of quality of life. The phase I trial of huanchansu for the treatment of patients with advanced hepatocellular carcinoma, non-small cell cancer, and pancreatic cancer was completed. In this trial, huanchansu showed to be well-tolerated and could result in disease stabilization in patient subsets. ICTCM has shown to be central in building new collaborative studies.
Differences in quality of life between American and Chinese breast cancer survivors. Support Care Cancer. Randomized, placebo-controlled trial of K1 acupoint acustimulation to prevent cisplatin-induced or oxaliplatin-induced nausea. Qigong Improves quality of life in women undergoing radiotherapy for breast cancer: results of a randomized controlled trial. Cancer , May 1; 9 Sham-controlled, randomized, feasibility trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma.
Eur J Cancer. Randomized controlled trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma. Oncol Rep. Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer. Electro-acupuncture to prevent prolonged postoperative ileus: a randomized clinical trial. World J Gastroenterol. Evid Based Complement Alternat Med.
Mind-body practices in cancer care. Current Oncology Reports, , 16 12 The objectives were to establish and maintain a library of authenticated TCM botanical extracts for scientific evaluation, to create a high throughput and combinatorial screening core to test the botanicals individually and in combination for their activity in bioassays relating to cancer, and to test extracts and fractions with optimal activity in relevant animal tumor models.
The Center consisted of two projects: selective cytotoxicity and angiogenesis, and three cores: administrative, botanical acquisition and authentication, and screening and chemical characterization.
Supportive Cancer Care with Chinese Medicine : William C.S. Cho :
The project was started in September with an expected ended date of July The findings of these projects may have translational potential into clinical investigations for cancer treatment. It may establish a future model for systemically evaluating botanicals traditionally used for the treatment and prevention of cancer. Since , this TCM botanical material collection over samples from above project was transferred to the Natural Products Branch, Division of Cancer Treatment and Diagnosis of NCI for continuing study on their anticancer activities using different screening and testing systems, including the NCI 60 human cancer cell lines.
Primary data have showed that certain TCM herb extracts can inhibit grow of many cancer cell lines. It contains over authenticated medicinal plant species which collectively represent the potential therapeutic contents of the major commonly used TCM herbal prescriptions. Using conventional lab chemical methods, each herb with different parts has been processed to becoming extracts with either organic solvent or aqueous extraction.
A total of samples of TCM plant species are in well and well plate formats and are accessible for drug discovery researchers worldwide.
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Developing a library of authenticated Traditional Chinese Medicinal TCM plants for systematic biological evaluation--rationale, methods and preliminary results from a Sino-American collaboration. At the meeting, participants from China, the U. So our current knowledge of traditional Chinese herbal remedies is limited.
Scientifc Evidence on the Supportive Cancer Care with Chinese Medicine
Some research suggests that other TCM methods, such as acupuncture, tai chi and massage, may help people cope with the physical and emotional side effects of conventional cancer treatments. Talk to your healthcare team if you are thinking about taking any traditional Chinese herbal remedies. Let your TCM practitioner know about your cancer diagnosis and any conventional cancer treatments you are having. Side effects of traditional Chinese herbal remedies will depend on the herbs and the combination of herbs in the preparation.
Other herbs used in TCM have been found to be contaminated with toxic metals such as lead, mercury or arsenic. We do not know if or how traditional Chinese herbal remedies affect the way conventional cancer treatments such as chemotherapy and radiation therapy work. Some traditional Chinese herbal remedies may interact with other herbs or over-the-counter drugs, which could be dangerous to your health.
This means that TCM practitioners must meet training and examination standards in order to practice traditional Chinese medicine using herbal remedies. Call us toll-free at Or write us. We will reply by email or phone if you leave us your details. If we are not able to reach you by phone, we will leave a voicemail message. Read more.
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Traditional Chinese herbal remedies Traditional Chinese herbal remedies are part of traditional Chinese medicine TCM and have been used in China for thousands of years. Traditional Chinese herbal remedies as a complementary therapy There is no evidence at this time that traditional Chinese herbal remedies can treat cancer itself.